Drug Type

Amitriptyline belongs to a group of drugs called tricyclic antidepressants.


Amitriptyline is available in 10mg, 25mg & 50mg Tablets. Normally the starting dose would be 10mg and can be increased over time to approximately 75mg. It is worth noting that Amitriptyline can take up to four weeks to start working.

UPDATE: I have recently been advised to increase to 100mg a day

How it works

According to research most people with Fibromyalgia are known to have an abnormally low supply of serotonin. This is a neurotransmitter that sends messages to the vital organs, via the blood chemistry. Serotonin interacts with substance P to determine pain levels and when released it has a similar effect to Noradrenaline in that it lightens mood and helps reduce pain levels.

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Serotonin and Noradrenaline are then reabsorbed back into the nerve cells and no longer have these beneficial effects. Amitriptyline works by preventing Serotonin and Noradrenaline being reabsorbed back into the nerve cells in the brain. This helps prolong both the mood lightening effects of Serotonin and Noradrenaline and their beneficial effect on pain.

Side Effects

As with any drug there may be side effects and it is always important to look out for sign of allergic reactions (Swelling of the lips, face or neck leading to severe difficulty in breathing; skin rash or hives) I have known Amitriptyline to cause a dry mouth in a few people, especially when starting taking the tablets. A frequent comment is that in the morning, (Amitriptyline is usually taken at night as it can help with sleep and can cause drowsiness) after taking Amitriptyline for the first time, you can feel very “spaced out”, so bear this in mind when you are considering taking Amitriptyline for the first time. If you have any concerns, contact your doctor. Other things that have been reported with drugs of this type (Not particularly Amitriptyline) include effects on the blood, effects on the heart and circulation, effects on the nervous system, effects on the anti-cholinergic system, allergic reactions, effects on the digestive system and effects on the hormone system.

Adverse Effects:

  • Dizziness
  • Weakness
  • Fatigue
  • Fluid retention
  • Needing to pass water often
  • Increased perspiration
  • Hair loss
  • Increased appetite
  • Weight gain
  • Links

    Amitriptyline on netdoctor.co.uk
    Amitriptyline on patient.co.uk

    This page will contain information on medications used in the treatment of Fibromyalgia and some of my personal experiences using them. This page is for information only and is not medical advice and everyone considering taking any medication should discuss the matter with their doctor first. If you have been prescribed any of these drugs, make sure you read the documentation with them, as this section is not meant to be a substitute for this important process.